Issue #41

Schizophrenia as a Disorder of Network Hierarchy: What Multi-Level fMRI Reveals

“Schizophrenia here looks less like a severed cable and more like a hierarchy that has folded in on itself — locally overwired, globally unintegrated.”

The Insula Reroutes in Untreated OCD — and Cognitive Inflexibility Follows the Wiring

“In untreated OCD the affective-interoceptive insula goes quiet toward the thalamus while the control insula over-grips sensorimotor cortex — and the tighter that grip, the harder the patient finds it to shift sets.”

A Dopamine Signature for Postpartum Psychosis — Read Off the Midbrain

“A standard MRI scanner just read a persistent dopamine signature off the midbrains of women who had recovered from postpartum psychosis — the first biological trace of a disorder we usually only see when it is already an emergency.”

Resetting the Clock: Triple Chronotherapy as a Fast-Acting Add-On for Bipolar and Unipolar Depression

“Chronotherapy buys you the first week — the week suicide risk is highest — but the maintenance plan still has to earn the rest.”

Measurement-Based Care Is No Longer Optional — and the Tooling Has Finally Caught Up

Cobenfy Meets the Ward: First Real-World Data Cools the "New Mechanism" Story

“A genuinely new mechanism is not the same as a genuinely better outcome — and treatment-resistant patients are where that distinction gets tested first.”