PSYREFLECT

Issue #82

October 15, 2026

#1Research

A psilocybin feasibility trial for treatment-resistant depression, run inside the English NHS

“The part of this model a specialist can recognize is the frame around the dosing day: preparation before it, scheduled integration after it.”

psilocybintreatment-resistant depressionfeasibility trialNHS
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#2Research

Self-criticism statistically mediates symptom change in MDMA-assisted therapy for PTSD

“The largest change in this trial was in self-judgment – a target a clinician can track in any trauma treatment.”

MDMA-assisted therapyPTSDself-compassionmediation analysis
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#3Tool

An expert panel of 12 builds a 165-item side-effects checklist for MDMA-assisted psychotherapy

“The tool puts the same symptom questions to the client before treatment, on the day of the sessions and in follow-up – a pattern that does not depend on the drug.”

MDMA-assisted psychotherapyside effectsDelphi studysafety monitoring
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#4Industry

A Russian review names the limits of the psychedelic trial base

“The question of whether psychedelics represent a powerful therapeutic tool or if their effects are overestimated remains unresolved.”

psychedelic-assisted therapyresearch methodologyplacebo controlnarrative review
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#5Industry

FDA's final guidance on psychedelic drug trials names 12 months of blinded follow-up the most informative design

“The blinded endpoint sits at 12 weeks and the most informative follow-up at typically 12 months, while many of the conditions themselves, the guidance notes, persist for months or years.”

psychedelic therapyFDA guidanceclinical trial designregulation
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#6Resource

UK psychiatrists' trial guidance asks for therapist pairs and case supervision

“Supervision of session material and a briefed next service are general practice; the therapist pair is tied to sessions of 6–8 hours.”

psychedelic-assisted therapyPARSresearch trialsclinical supervision
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