August 27, 2026
“The authors state their own conclusion this way: valproate exposure was associated with an increased risk of polycystic ovary syndrome in women with bipolar disorder or epilepsy, with the strongest associations observed for current cumulative exposure and additional risk apparent at high cumulative dosages, while overall cumulative exposure showed a less clear dose-response pattern.”
“The authors conclude that "Data suggest a favorable benefit-risk profile for AOM 400 versus placebo as a long-term maintenance treatment for BP-I", and all four of the paper's benefit-harm ratios are built on who stopped attending, while the akathisia in 21.2% of patients and the weight gain in 23.5% are printed one table earlier and never enter them.”
“The sentence the authors placed in their conclusion and not in their abstract: lithium treatment should neither be withheld nor continued reflexively solely on the basis of renal concerns, and what replaces the reflex is an individualized, trajectory-based assessment that balances substantial therapeutic benefit against renal risk, preserving lithium's role as a first-line treatment while safeguarding long-term patient health.”
“A switch or augmentation of therapy is required by no less than a third of patients taking antipsychotics, the author concludes on pages 31 to 32, and quetiapine is perceived by psychiatrists as a highly effective and well tolerated antipsychotic with a broad spectrum of action going beyond the official indications; his own closing sentence adds that doctors' ideas about the antiresistant properties of the drug require confirmation in real clinical practice and in randomised trials. The article is sponsored by NovaMedica, and a patient entered the programme only if the treating doctor had already decided on quetiapine.”
“The authors' head conclusion is that mono- and combination therapy exhibited substantial heterogeneity in their effectiveness for preventing psychiatric hospitalisation, and that hospitalisation, together with hospitalisation of any cause, is the whole of what this publication measures.”
“The guideline times every taper to the week and specifies immediate withdrawal when the liver or the blood count says so; for planned stopping of maintenance treatment, sections 1.7 and 1.10 name no threshold in episodes or months of remission and leave the moment inside a required conversation.”