July 20, 2026
“In psychosis risk the problem may not be that the world stops offering rewards, but that the brain stops paying itself for its own effort.”
“Depression here reads less as a storm of negative predictions than as a quiet letting-go of the wheel – the brain stops simulating consequences and lets choice wander from one option to the next.”
“A cortex still emitting a vigorous prediction error has more plastic reserve for iTBS to mobilise, and its mismatch negativity shows it before the first pulse.”
“A model can be mathematically elegant and mechanistically plausible and still be clinically useless if the same patient scores differently next week.”
“Before prediction error can serve as a biomarker, someone has to prove the signal means the same thing twice, and this study shows how easily it does not.”
“For a clinician who has read Hohwy or Clark and wants to move from metaphor to method, the CPC is the rare course that hands you the equations and the code rather than only the story.”