July 2, 2026
“In a cohort of 143 first-episode psychosis patients, clinical red flags plus serum testing caught four of five autoimmune encephalitis cases; the fifth was visible only in cerebrospinal fluid.”
“A measure that separates patients from controls yet ignores how ill they are on any given day is behaving like a trait marker – which is exactly what a diagnostic test should do.”
“The early signature of psychosis may not be a brain region going quiet, but a circuit whose information flow has quietly reversed.”
“The mechanism that lets a healthy listener reconstruct speech in a noisy room is, when its gain is set too high, the same mechanism that manufactures a voice that was never there.”
“A six-item scale that reproduces the positive/negative structure of psychosis is not a compromise; it is a tracker a real clinic can actually use twice.”
“Schizophrenia is not an expensive illness because it is treated; it is expensive because, too often, it is not.”