June 29, 2026
“When a depressed patient's relationship with food is as turbulent as their mood, the diagnosis may not yet be telling the whole story.”
“Read subregion by subregion, the insula in bipolar disorder is part state marker and part trait marker, and averaging the two together had been hiding both.”
“The marker speaks most clearly when mood is euthymic or elevated and falls silent under depression, which is exactly the behavior a true mania-vulnerability signal should show.”
“In this high-risk inpatient sample, how high or low affect sat predicted suicidal ideation better than how violently it swung.”
“A screen that performs best exactly where diagnosis is hardest is doing the clinical work that matters most.”
“When the average road to a bipolar diagnosis runs 9.5 years, the failure is rarely one clinician's blind spot – it is a pathway built to miss the symptom that matters most.”