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2026-08-06 | RESEARCH

A psilocybin feasibility trial for treatment-resistant depression, run inside the English NHS

The part of this model a specialist can recognize is the frame around the dosing day: preparation before it, scheduled integration after it.

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2025-05-07 | RESEARCH

Self-criticism statistically mediates symptom change in MDMA-assisted therapy for PTSD

The largest change in this trial was in self-judgment – a target a clinician can track in any trauma treatment.

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2026-05-11 | TOOL

An expert panel of 12 builds a 165-item side-effects checklist for MDMA-assisted psychotherapy

The tool puts the same symptom questions to the client before treatment, on the day of the sessions and in follow-up – a pattern that does not depend on the drug.

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2025-03-15 | INDUSTRY

A Russian review names the limits of the psychedelic trial base

The question of whether psychedelics represent a powerful therapeutic tool or if their effects are overestimated remains unresolved.

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RESEARCH8
RESEARCH
A psilocybin feasibility trial for treatment-resistant depression, run inside the English NHS
The part of this model a specialist can recognize is the frame around the dosing day: preparation before it, scheduled integration after it.
Nature Medicine · 2026-08-06Read →
RESEARCH
Self-criticism statistically mediates symptom change in MDMA-assisted therapy for PTSD
The largest change in this trial was in self-judgment – a target a clinician can track in any trauma treatment.
European Journal of Psychotraumatology · 2025-05-07Read →
RESEARCH
A 40-second and a 28-minute TMS session showed no significant difference in Y-BOCS change in OCD
Fifteen sessions add up to seven hours of stimulation in one arm and ten minutes in the other, with Y-BOCS falling in both.
CNS Spectrums · 2025-08-26Read →
RESEARCH
In a small pilot, heart-rate variability in OCD rose later after pleasant videos
In this sample, heart-rate variability rose after pleasant videos in healthy controls and only toward the end of the session in people with OCD.
Brain Sciences · 2026-08-09Read →
RESEARCH
Omega-3 capsules and placebo did not separate in a 135-person European trial of teenagers at risk of psychosis
In this trial, six months of omega-3 capsules did not change the rate of transition to psychosis or symptom severity compared with placebo in young people at ultra-high risk.
Schizophrenia Bulletin · 2024-10-25Read →
RESEARCH
Two weeks of delivered meals, and a depression score that fell
When a client says a change in eating has lifted their mood, ask what else changed that week: who became involved, how the day is structured and what they expected.
Scientific Reports · 2026-04-25Read →
RESEARCH
Placebo arms in acute schizophrenia trials improve, plateau and sometimes worsen
In 6 of the 48 placebo arms, the PANSS Total score ended above its baseline value.
Schizophrenia Bulletin · 2025-03-19Read →
RESEARCH
One tocilizumab infusion for depression that antidepressants had not moved
For the client who has tried everything, persistent fatigue and bodily heaviness may be a prompt to ask about inflammation rather than to change the antidepressant again.
JAMA Psychiatry · 2026-05-20Read →
CLINICAL TOOL5
TOOL
An expert panel of 12 builds a 165-item side-effects checklist for MDMA-assisted psychotherapy
The tool puts the same symptom questions to the client before treatment, on the day of the sessions and in follow-up – a pattern that does not depend on the drug.
BMJ Open · 2026-05-11Read →
TOOL
A 12-item daily text-message survey asks people with OCD how they feel, not only how often
The scale asks how often, and then what the person felt: anxiety, guilt, helplessness, disgust and burden, after obsessions and after compulsions.
JMIR Formative Research · 2026-03-30Read →
TOOL
Nutritional deficiency in 111 Russian patients with Alzheimer's and Parkinson's disease, and what travelled with it
In 111 patients with Alzheimer's or Parkinson's disease, nutritional deficiency or risk was found in 31 and went with chewing and swallowing problems and with depression.
Журнал неврологии и психиатрии им. С.С. Корсакова · 2025-12Read →
TOOL
Compassion focused therapy and prolonged exposure compared in 41 adults with complex PTSD
In this trial, symptom reduction in complex PTSD did not differ between CFT and prolonged exposure, so the choice can rest on what the client can tolerate and is ready for.
Revista de Psicopatología y Psicología Clínica · 2025Read →
TOOL
A Jumping-to-Conclusions Test Finds a Narrower Signature in Adolescent Depression
The depressed adolescents in this study did not jump to conclusions the way psychotic patients do - they lowered the bar only when the decision was already easy.
Journal of Psychiatric Research · 2026-05-20Read →
INDUSTRY9
INDUSTRY
A Russian review names the limits of the psychedelic trial base
The question of whether psychedelics represent a powerful therapeutic tool or if their effects are overestimated remains unresolved.
Neurology Bulletin (Nevrologicheskiy Vestnik) · 2025-03-15Read →
INDUSTRY
FDA's final guidance on psychedelic drug trials names 12 months of blinded follow-up the most informative design
The blinded endpoint sits at 12 weeks and the most informative follow-up at typically 12 months, while many of the conditions themselves, the guidance notes, persist for months or years.
U.S. Food and Drug Administration · 2026-07-14Read →
INDUSTRY
NICE draft guideline replaces the OCD treatment ladder with matched care
The draft does not promise a shorter queue. It asks that the first offer be decided by the person's clinical picture and preference, and that the wait be explained.
NICE (National Institute for Health and Care Excellence) · 2026-09-17Read →
INDUSTRY
Over 90% of German adults with OCD say they would do exposure therapy, and half of those with CBT had it
In this sample, stated willingness was high: over 90% said they would do ERP if nothing stood in the way, and the barriers respondents named most were external.
BMC Psychiatry · 2025-03-11Read →
INDUSTRY
China's draft rules for probiotic supplements ask for a strain number and a live count
The draft requires a strain number and a live count for every probiotic health food. It says nothing about mood.
State Administration for Market Regulation (SAMR), China · 2026-07-24Read →
INDUSTRY
A European psychiatry paper puts diet first and never mentions the gut
Nutritional support must be extended to both patients and families.
European Psychiatry (European Psychiatric Association) · 2025-11-18Read →
INDUSTRY
German group basic care grows fast and its regulator cannot say why
G-BA's own reading of its figures: the descriptive analyses cannot show whether basic group care leads patients into group therapy.
Gemeinsamer Bundesausschuss (G-BA) · 2026-05-05Read →
INDUSTRY
Medicare now lets clinicians bill for antidepressant tapering, and leaves the taper itself undefined
CMS has agreed to pay for the taper, but it names no protocol for it. The clinician still has to write the plan.
Centers for Medicare & Medicaid Services (CMS) · 2026-05-04Read →
INDUSTRY
Wellcome Funds UK Regulators to Build an AI Testing Sandbox for Mental Health Apps
Regulators are building a faster lane for AI risk-screening tools, not a separate track for the computational biomarkers that gave the field its name.
GOV.UK · 2025-11-27Read →
RESOURCES4
RESOURCE
UK psychiatrists' trial guidance asks for therapist pairs and case supervision
Supervision of session material and a briefed next service are general practice; the therapist pair is tied to sessions of 6–8 hours.
Royal College of Psychiatrists · 2025-09Read →
RESOURCE
An Indian OCD guideline puts a number on an adequate trial
The guideline counts a trial as adequate at 12 weeks of an SSRI or 12–20 sessions of exposure and response prevention.
Indian Journal of Psychiatry · 2026-01-27Read →
RESOURCE
A Canadian health service gives clinicians ready sentences for talking about food
Eating well is one part of managing your (insert mental health condition), along with other treatments your healthcare provider may have suggested.
Alberta Health Services (Canada), Nutrition Services, Professional Education and Practice · 2024-06Read →
RESOURCE
A Russian ethics code tells the client before session one that online therapy may leak
Before the first online session the therapist tells the client that confidentiality cannot be guaranteed at the in-person level, and agrees in advance who bears the cost of a technical failure.
Общероссийская Профессиональная Психотерапевтическая Лига (ОППЛ) · 2026Read →

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