Self-Injury in Epilepsy: Not the Severe Subgroup Clinicians Assume

Comorbid epilepsy did not make self-injurers sicker — it pointed to a different road to the same behavior.

When fullness fails to quiet the brain: a reward-feedback signature of food addiction

Fullness silenced the healthy brain's pursuit of food; in food addiction, it amplified it — the off-switch did not fire.

Two Fears, Two Brains: Why "Fear of Fear" and "Fear of the Unknown" Drive Avoidance Through Separate Circuits

"Fear of fear" and "fear of the unknown" are not two dials on the same anxious brain — they drive avoidance through separate circuits, at separate moments of decision.

How Cohesion Builds in an Online Therapy Group: A Word-Level Map of Process

Cohesion is not a switch the group flips; it is the yield on relational investment made weeks earlier — and in an online group, that runway may simply be longer.

Late-Life Depression Splits Into Four Biological Subtypes — and Each Responds Differently to Treatment

A failed antidepressant in an older patient is more often the wrong drug for the right biology than a resistant illness — and the difference may be visible in a baseline blood panel.

When Mood and Memory Share a Lesion: Amygdalar and Thalamic Substrates of Late-Life Vascular Depression

In vascular late-life depression, mood and memory are not comorbid — they are two readouts of one amygdalar lesion.

When the screen is the room: which part of the alliance still carries the work

Online, the alliance still carries the work — but it carries it through agreement on tasks and goals, not through the warmth of the bond.

The circuit that makes accelerated TMS work: a fronto-insular pathway, mapped from mouse to human

Accelerated TMS does not just wake up the prefrontal cortex — it recruits a prefrontal-to-insula circuit that is necessary and sufficient for the antidepressant effect.

The Mind Behind the Face Pain: Alexithymia and Cognitive Slowing in Trigeminal Neuralgia

Severe facial pain is treated as a surgical wiring fault, but the patient who lives with it often cannot name what they feel — and that, not the vessel, is what the therapist meets.

When the Patient Hears the Words but Not the Meaning: Novel-Metaphor Failure Along the Schizotypy Continuum

A patient can pass every worn-out idiom and still be unable to build a single fresh metaphor — and it is the fresh ones that conversation, therapy, and recovery actually require.

Mapping the Off-Switch: Personalized Brain Targets for Refractory OCD

The advance is not a new target but a new question — not "where do we stimulate for OCD," but "where, in this particular brain, does the symptom signal live, and which site switches it off."

When Two Brains Fail to Sync: A Neural Marker of Social Difficulty in Autistic Preschoolers

Autistic social difficulty here is not a fault inside one brain but a failure of two brains to couple — which makes the dyad, not the child, the proper target of assessment and intervention.

The Insula Reroutes in Untreated OCD — and Cognitive Inflexibility Follows the Wiring

In untreated OCD the affective-interoceptive insula goes quiet toward the thalamus while the control insula over-grips sensorimotor cortex — and the tighter that grip, the harder the patient finds it to shift sets.

A Dopamine Signature for Postpartum Psychosis — Read Off the Midbrain

A standard MRI scanner just read a persistent dopamine signature off the midbrains of women who had recovered from postpartum psychosis — the first biological trace of a disorder we usually only see when it is already an emergency.

Schizophrenia as a Disorder of Network Hierarchy: What Multi-Level fMRI Reveals

Schizophrenia here looks less like a severed cable and more like a hierarchy that has folded in on itself — locally overwired, globally unintegrated.

Resetting the Clock: Triple Chronotherapy as a Fast-Acting Add-On for Bipolar and Unipolar Depression

Chronotherapy buys you the first week — the week suicide risk is highest — but the maintenance plan still has to earn the rest.

Psilocybin Rewires the Cortex Selectively — and Only Where Neurons Fire

Psilocybin does not write change into the cortex — it opens a window in which whatever circuits are firing get to do the writing.

How Should We Score the Self-Compassion Scale? A Meta-Analytic Verdict

Self-compassion behaves like a single dial turned from cold to warm — not two switches — and the scale should be read accordingly.

The GDS-5: a five-item depression screen for older adults who tire of long forms

A five-item screen with 0.98 sensitivity is not a diagnostic instrument — it is a door you open quickly so that no depressed older patient walks past it unseen.

A Six-Item Screener Outperforms the MDQ for Bipolar Depression in Adolescents

A six-item screen that out-discriminates the MDQ buys you the one thing that matters in adolescent depression — a reason to ask about hypomania before you reach for the prescription pad.

Measurement-Based Care Is No Longer Optional — and the Tooling Has Finally Caught Up

OECD Puts a Price on Inaction: €76bn a Year and 1.7% of GDP Lost to Mental Ill Health

Two-thirds of Europeans who need mental health care receive none — and the OECD now estimates the resulting drag at 1.7% of GDP every year through 2050.

Bereavement Leave in 2026: The Policy Patchwork Finally Moves, But Still Trails the Clinical Picture of Grief

Statutory bereavement leave is finally being measured in weeks, but prolonged grief disorder is measured in years — and the people who fall furthest are the ones the policy still cannot see.

UNESCO Sets the First Global Standard for Neurotechnology Ethics — and It Reaches Into Your Consulting Room

Soft law writes the vocabulary before hard law writes the rules — and mental privacy has just entered the global lexicon as a right worth protecting.

Cobenfy Meets the Ward: First Real-World Data Cools the "New Mechanism" Story

A genuinely new mechanism is not the same as a genuinely better outcome — and treatment-resistant patients are where that distinction gets tested first.

Three Years In: What Oregon's Measure 109 Data Now Tells Clinicians About Real-World Psilocybin Services

Oregon's three-year data shows that legal psilocybin access can be built and sustained — but the model that emerged is adult-use under facilitator supervision, not the medicalised treatment most clinicians were anticipating, and the gap between them is now structural rather than temporary.