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2026-04-16 | RESEARCH

When the brain stops rewarding its own effort

In psychosis risk the problem may not be that the world stops offering rewards, but that the brain stops paying itself for its own effort.

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2026-01-22 | RESEARCH

When the Depressed Brain Stops Simulating: A Model-Based Learning Deficit

Depression here reads less as a storm of negative predictions than as a quiet letting-go of the wheel – the brain stops simulating consequences and lets choice wander from one option to the next.

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2026-05-03 | TOOL

Mismatch Negativity: A Prediction-Error Index That Flags iTBS Responders in Depression

A cortex still emitting a vigorous prediction error has more plastic reserve for iTBS to mobilise, and its mismatch negativity shows it before the first pulse.

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2025-10-10 | INDUSTRY

Computational Psychiatry, a Decade In: The Pivot to Trials and the Reliability Problem Underneath It

A model can be mathematically elegant and mechanistically plausible and still be clinically useless if the same patient scores differently next week.

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RESEARCH12
RESEARCH
When the brain stops rewarding its own effort
In psychosis risk the problem may not be that the world stops offering rewards, but that the brain stops paying itself for its own effort.
Schizophrenia Research · 2026-04-16Read
RESEARCH
When the Depressed Brain Stops Simulating: A Model-Based Learning Deficit
Depression here reads less as a storm of negative predictions than as a quiet letting-go of the wheel – the brain stops simulating consequences and lets choice wander from one option to the next.
Annals of General Psychiatry · 2026-01-22Read
RESEARCH
Ranking Brain Stimulation for Depression: Bilateral Protocols and Focused Ultrasound Come Out on Top
For a depressive episode, the ranking preliminarily favors bilateral prefrontal stimulation, and the older left-sided high-frequency default is no longer the automatic choice.
Psychiatry and Clinical Neurosciences · 2025-11-11Read
RESEARCH
Timing Is the Dose: Morning Bright Light Reaches Anhedonia in Depression
Same lamp, same lux, same thirty minutes – given in the morning, the effect on anhedonia stands out; the circadian clock, not the mood score, seems to be the target.
Journal of Affective Disorders · 2026-03-03Read
RESEARCH
When the Mind Wanders Off the Breath: A Signature for Interoceptive Attention Lapses
The moment attention slips off the breath is not noise to be averaged away; it is a network-level event, and returning from it is the skill the practice actually builds.
Cognitive, Affective & Behavioral Neuroscience · 2026-06-23Read
RESEARCH
The Body Keeps Time: How Heart Rate Bends the Sense of Duration
When the heart slows, the felt clock slows with it, and much of that happens beneath anything the patient can report.
Frontiers in Psychology · 2025-07-03Read
RESEARCH
Not Whether the Body Is Heard, but How It Is Trusted: Interoception and Suicide Risk
For suicide risk, the meaningful interoceptive variable is not how precisely the body is detected but whether it is trusted and can be used to steady distress.
Nature Human Behaviour · 2026-07-01Read
RESEARCH
The Brain's Heartbeat Signal Is Not a Biomarker Yet: A Cautionary Meta-Analysis
The heartbeat evoked potential is the field's favourite objective marker of interoception, and it cannot yet tell clinical brains from healthy ones.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · 2026-05-04Read
RESEARCH
How patients talk about illness: four metaphor families and the one that quietly heals
It is not the metaphor's subject that heals or harms, but the emotional tone it carries – the same illness framed as a fight or as a game asks two very different things of the patient.
Communication & Medicine · 2024-11-01Read
RESEARCH
When Metaphor Reframes Faster Than Logic: A Neural Signature for Cognitive Restructuring
A reframe the client logically accepts but cannot feel rarely survives the next bad week; a metaphor that lands recruits memory and semantic systems that help it hold.
Neuroscience · 2023-09-07Read
RESEARCH
Three emotional faces of adult ADHD, and the amygdala circuit that separates them
The brain signature of emotion dysregulation in adult ADHD appeared not in the most impaired patients but in the moderate middle, hinting that it is a circuit configuration rather than a simple severity dial.
Journal of Affective Disorders · 2026-04-09Read
RESEARCH
The Autistic Brain Ages on a Different Schedule: A Fluid-Clearance Biomarker for Memory Decline
Memory difficulty in an autistic adult may not be a fixed trait but the visible end of a fluid-clearance cascade that begins in the brain's plumbing.
Molecular Autism · 2026-02-18Read
CLINICAL TOOL4
TOOL
Mismatch Negativity: A Prediction-Error Index That Flags iTBS Responders in Depression
A cortex still emitting a vigorous prediction error has more plastic reserve for iTBS to mobilise, and its mismatch negativity shows it before the first pulse.
Journal of Affective Disorders · 2026-05-03Read
TOOL
Eleven Items to Flag Borderline Features in Early Adolescence
A total of 26 or more is a reason to assess, never a diagnosis to hand out.
Psychiatriki · 2025-12-20Read
TOOL
Two Scales, Two Constructs: Interoceptive Accuracy Is Not Interoceptive Attention
In this data, self-reported attention to the body and self-reported accuracy pull apart: attention without accuracy tracked more distress, not less.
Journal of Health Psychology · 2026-05-13Read
TOOL
BrainACT: one metaphor to carry an entire therapy when the patient cannot hold the whole
When the patient cannot carry the whole therapy, give them one metaphor to carry instead, and build everything else onto it.
Clinical Rehabilitation · 2023-02-07Read
INDUSTRY7
INDUSTRY
Computational Psychiatry, a Decade In: The Pivot to Trials and the Reliability Problem Underneath It
A model can be mathematically elegant and mechanistically plausible and still be clinically useless if the same patient scores differently next week.
Nature Computational Science · 2025-10-10Read
INDUSTRY
Before Prediction Error Becomes a Biomarker: A Moscow Lab Reads the Fine Print
Before prediction error can serve as a biomarker, someone has to prove the signal means the same thing twice, and this study shows how easily it does not.
Brain Sciences · 2026-04-22Read
INDUSTRY
Medicare Puts Digital Therapeutics on the Fee Schedule – and Adds ADHD for 2026
The largest public payer for America's oldest patients has decided that validated software is a billable clinical tool, not wellness content.
Centers for Medicare & Medicaid Services (CMS) · 2025-10-31Read
INDUSTRY
When Burnout Reaches the Chart: Moscow Data on Psychiatrist Distress and Inpatient Care
Burnout is not only a clinician's private burden – in these records it showed up as more correctors, more polypharmacy, and longer stays for the patients in that clinician's care.
Neurology, Neuropsychiatry, Psychosomatics (IMA Press) · 2024-12-17Read
INDUSTRY
The Wearable Says It Tracks Your Nervous System. The Evidence Base Is 18 Studies.
The wearable is reading heart rate variability; the claim that it reads your interoception is a marketing step the science has taken only twice in five years.
Frontiers in Digital Health · 2026-02-09Read
INDUSTRY
What Clinicians Should Actually Understand About "AI Psychosis"
The clinical question is not whether a patient uses a chatbot, but what role it has come to play in their symptoms.
The Lancet Digital Health · 2026-03-14Read
INDUSTRY
The Hands Know More Than the Words: Why Embodied Meaning Is Where AI Stalls at the Therapy Door
The meaning a clinician catches in a half-finished gesture is exactly the kind that does not survive being turned into tokens.
Journal of Bioethical Inquiry · 2025-09-11Read
RESOURCES3
RESOURCE
Predictive Brains, Taught as Method: Zurich's Computational Psychiatry Course
For a clinician who has read Hohwy or Clark and wants to move from metaphor to method, the CPC is the rare course that hands you the equations and the code rather than only the story.
Translational Neuromodeling Unit (TNU), University of Zurich & ETH Zurich · 2026-09-07 – course dates 7–12 September 2026Read
RESOURCE
ISTSS 42nd Annual Meeting: the field's global trauma-science forum, San Antonio, September 2026
ISTSS is the field's flagship global trauma-science congress, and its income-tiered registration means four days of calibrating against the primary literature are not reserved for well-funded Western institutions.
International Society for Traumatic Stress Studies (ISTSS) · 2026-09-23Read
RESOURCE
The Reference Text for Using Metaphor Deliberately, Not Decoratively
A metaphor is not a flourish – it is a relational frame that carries the function of one experience into another, which is exactly why it can move a patient when an argument cannot.
Context Press / New Harbinger · 2017-08-01Read

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